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mTOR Inhibitor, WYE-132

A sub-nanomolar potent mTOR inhibitor
Catalog #: 2256
SKU-Size Size Price Qty
2256-500 500 µg
2256-1000 1 mg
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Product Details

Alternate Name 1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea; WYE-125132
Appearance White solid
CAS # 1144068-46-1
Molecular Formula C₂₇H₃₃N₇O
Molecular Weight 519.6
Purity ≥98% by HPLC
Solubility DMSO (50 mg/ml)
InChi InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
PubChem CID 25260757
MDL Number MFCD16038851
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo.

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