Product Details
| Cat # +Size | 3786-100 |
|---|---|
| Size | 100 μl |
| Antibody Target | mTOR |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide of human mTOR |
| Accession # | NP_004949.1 |
| Gene ID | 2475 |
| Appearance | Colorless liquid |
| Formulation | 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot |
| Application & Usage | Western blotting (1:250 – 1:2500). Rat liver tissue lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the mTOR of human, mouse, and rat origins. Reactivity to other spe |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.
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