Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

MRTX-1257

A potent, selective, and irreversible covalent inhibitor of KRAS G12C
Catalog #: B2614
SKU-Size Size Price Qty
B2614-1 1 mg
$85.00
B2614-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name MRTZ1257, 2-((S)-1-acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile, MRTX1257
Appearance White to off-white solid
CAS # 2206736-04-9
Molecular Formula C₃₃H₃₉N₇O₂
Molecular Weight 565.72
Purity ≥98% by HPLC
Solubility >40 mg/ml in DMSO
SMILES CC1=C2C(=CC=C1)C=CC=C2N3CCC4=C(C3)N=C(N=C4N5CCN(C(C5)CC#N)C(=O)C=C)OCC6CCCN6C
InChi InChI=1S/C33H39N7O2/c1-4-30(41)40-19-18-39(20-25(40)13-15-34)32-27-14-17-38(29-12-6-10-24-9-5-8-23(2)31(24)29)21-28(27)35-33(36-32)42-22-26-11-7-16-37(26)3/h4-6,8-10,12,25-26H,1,7,11,13-14,16-22H2,2-3H3
InChi Key YRYQLVCTQFBRLD-UHFFFAOYSA-N
PubChem CID 134326100
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MRTX-1257 is a potent, selective, and irreversible covalent inhibitor of KRAS G12C. MRTX-1257 inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC₅₀ of 0.9 nM. Displays high selectivity for the Cys12 of KRAS G12C in NCI-H358 cells over other cysteines. Exhibits robust target engagement in vivo.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.