A potent and selective, small molecule Toll-like receptor (TLR) 8 agonist
Catalog #: B1594 | abID:

Product Details

Alternate Name 3H-1-Benzazepine-4-carboxamide, 2-amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl; VTX-2337
Appearance Crystalline solid
CAS # 926927-61-9
Molecular Formula C₂₈H₃₄N₄O₂
Molecular Weight 458.6
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
InChi InChI=1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-18H,3-6,13-16,19H2,1-2H3,(H2,29,30)
PubChem CID 16049404
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Motolimod (VTX-2337) is a potent and selective, small molecule Toll-like receptor (TLR) 8 agonist (EC₅₀ = 100 nM) that stimulates natural killer (NK) cells, dendritic cells, and monocytes. Useful in immunotherapy for multiple oncology indications, including squamous cell carcinoma of the head and neck (SCCHN). 

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