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A potent multikinase inhibitor selective to VEGFRs and PDGFrs
Catalog #: 2022
SKU-Size Size Price Qty
2022-5 5 mg
2022-25 25 mg
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Product Details

Alternate Name AMG-706
Appearance White solid
CAS # 453562-69-1
Molecular Formula C₂₂H₂₃N₅O
Molecular Weight 373.45
Purity ≥98% by HPLC
Solubility DMSO (200 mg/ml) or EtOH (40 mg/ml)
InChi InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
PubChem CID 11667893
MDL Number MFCD10567689
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. Motesanib, also known as AMG-706, is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC₅₀ values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit). It also potently inhibits angiogenesis and induces regression in tumor xenografts.

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