Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit (Fluorometric)

Only kit on the market to screen monoamine oxidase A (MAO-A) inhibitors
Catalog #: K796 | abID: ab284510

Product Details

abID ab284510
Cat # +Size K796-100
Size 100 assays
Detection Method Fluorescence (Ex/Em = 535/587 nm)
Applications Screening/studying/characterizing MAO-A inhibitors
Features & Benefits • Rapid & sensitive
• High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase A
• Includes Inhibitor Control [Clorgyline]
Kit Components • MAO-A Assay Buffer
• OxiRed™ Probe (in DMSO)
• MAO-A Enzyme (Lyophilized)
• MAO-A Substrate (Lyophilized)
• Developer (Lyophilized)
• Inhibitor Control (Clorgyline) (Lyophilized)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Monoamine oxidases (MAO, EC 1.4.3.4) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-A can oxidize primary amines such as serotonin and norepinephrine. MAO-A is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been implicated in panic, anxiety, and depression. Several MAO-A specific inhibitors such as clorgyline, brofaromine, toloxatone, tetrindole, etc. have been used as antidepressants, but their usage has been limited due to side effects. BioVision’s MAO-A Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-A inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.


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