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Monastrol

A potent, cell-permeable, small molecule mitosis inhibitor
Catalog #: B2269
SKU-Size Size Price Qty
B2269-5 5 mg
$125.00
B2269-25 25 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Appearance White solid
CAS # 254753-54-3
Molecular Formula C₁₄H₁₆N₂O₃S
Molecular Weight 292.35
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml) or EtOH (>5 mg/ml)
SMILES CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
InChi InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChi Key LOBCDGHHHHGHFA-UHFFFAOYSA-N
PubChem CID 2987927
MDL Number MFCD00813077
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor. It arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC₅₀ = 14 μM).


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