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MMP-9, Active, Human Recombinant

A Protein involved in breakdown of extracellular matrix
Catalog #: P1567
SKU-Size Size Price Qty
P1567-10 10 μg
$295.00
P1567-50 50 μg
$455.00
More Sizes Get Quote

Product Details

Alternate Name Matrix Metalloproteinase-9, Gelatinase B, 92 kDa Type IV Collagenase, MMP9, CLG4B, GELB, MANDP2
Gene Symbol MMP-9
Gene ID 4319
Accession # P14780
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized from a proprietary buffer
Molecular Weight 41.3 KDa (N-terminal His-Tag)
Purity by SDS-PAGE >95%
Biological Activity The activity was determined using fluorogenic substrate Mca-PLGL-Dpa-AR-NH2. The specific activity is ≥ 200 µU/µg.
Reconstitution Instructions Reconstitute with pre-chilled 30% Glycerol/H2O solution to 0.1 µg/µl and incubate on ice until it completely dissolves. Aliquot and store the reconstituted MMP-9 at -20°C. Stable for 2 months after reconstitution.
Amino Acid Sequence aa 107-457
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B, is the mostly studied MMP, due to its fundamental role in cancer biology, autoimmune disease, and other conditions. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP-9 is structurally a multi-domain metalloenzyme, composed of a prodomain, a catalytic domain, a gelatin binding domain, a metal-binding domain, and a carboxyl terminal hemopexin like domain. This active human MMP-9 is composed of the catalytic domain, a gelatin binding domain, and a metal-binding domain (AA 107-457). The protein was expressed in E. coli and purified and refolded using proprietary techniques.


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