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MMP-3 Inhibitor Screening Kit (Fluorometric)

Sensitive Assay to Screen MMP-3 Inhibitors, HTS
Catalog #: K793
$510.00

Product Details

Cat # +Size K793-100
Size 100 assays
Detection Method Fluorescence (Ex/Em 325/393 nm)
Applications The kit can be used to screen inhibitors of MMP-3.
Features & Benefits • Simple procedure; takes ~ less than 40 minutes
• Fast and convenient
Kit Components • MMP-3 Assay Buffer
• MMP-3 Substrate
• MMP-3 Enzyme (lyophilized)
• Inhibitor Control (0.1 mM GM6001)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The matrix metalloproteinase-3 (MMP-3, stromelysin-1) exhibits a number of activities that would make it a particularly good tumor promoter. Like several other MMPs, MMP-3 was first cloned and later recloned as a cancer-specific gene. In addition to degrading numerous extracellular matrix components, MMP-3 can activate gelatinase B, the collagenases and several serpin-type serine proteinase inhibitors. Moreover, it can release a number of cell surface molecules, including E-cadherin, a known contributor to cancer development. In BioVision’s MMP-3 Inhibitor Screening Assay Kit, MMP-3 hydrolyzes a specific FRET substrate to release the quenched fluorescent group Mca, which can be detected fluorometrically at Em/Ex=325/393 nm. The kit provides a rapid, simple, sensitive, and reliable test suitable as a high throughput screening assay of MMP-3 inhibition. In addition, we also offer a human recombinant MMP-3 enzyme (Biovision #7783) and a MMP-3 Activity Assay Kit (Biovision #K783-100), separately.


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