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MMP-3 Activity Fluorometric Assay Kit

Highly Sensitive Assay, HTS
Catalog #: K783

In stock

$405.00

Product Details

Cat # +Size K783-100
Size 100 assays
Detection Method Fluorescence (Ex/Em 325/393 nm)
Species Reactivity Mammalian
Applications The assay sensitivity is < 50 µU.
Features & Benefits • Sensitive assays for measuring MMP-3 in various biological samples
Kit Components • MMP-3 Assay Buffer
• MMP-3 Substrate br>• Mca Standard (1mM)
• MMP-3 Positive Control
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The matrix metalloproteinase-3 (MMP-3, stromelysin-1) exhibits a number of activities that would make it a particularly good tumor promoter. Like several other MMPs, MMP-3 was first cloned and later recloned as a cancer-specific gene. In addition to degrading numerous extracellular matrix components, MMP-3 can activate gelatinase B, the collagenases and several serpin-type serine proteinase inhibitors. Moreover, it can release a number of cell surface molecules, including E-cadherin, a known contributor to cancer development. In BioVision’s MMP-3 Assay Kit, MMP-3 hydrolyzes a specific FRET substrate to release the quenched fluorescent group Mca, which can be detected fluorometrically at Ex/Em = 325/393 nm. The kit provides a rapid, simple, sensitive and reliable test which can also be used as a high throughput assay of MMP-3 activity. The assay sensitivity is < 50 µU. This kit can be used with our MMP-3 inhibitor, GM6001 (Biovision #1799) as a control. In addition, we also offer a human recombinant MMP-3 enzyme (Biovision #7783) and a MMP-3 inhibitor Screening Kit (Biovision #K793-100), separately.


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