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MMP-14, Active, Human Recombinant

>90% Pure, Active, Human Recombinant MMP-14
Catalog #: 8009
SKU-Size Size Price Qty
8009-10 10 µg
$245.00
8009-50 50 µg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Matrix metalloproteinase-14, MT1-MMP
Gene Symbol MMP14
Gene ID 4323
Accession # P50281
Source E. coli
Appearance Lyophilized powder
Physical Form Description Lyophilized from propriety buffer
Molecular Weight ~ 24.0 kDa (112-318 aa)
Purity by SDS-PAGE ≥90%
Reconstitution Instructions Reconstitute with dH2O
Amino Acid Sequence 112-318 aa
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

The Matrix metalloproteinase-14 (MMP-14) belongs to a family of zinc-dependent endopeptidases. The ability of MMP-14 to degrade type I collagen, and activate pro-MMP-2 and pro-MMP-9 makes it a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. MMP-14 is structurally a multi-domain metalloenzyme, composed of a prodomain, a metal-binding catalytic domain, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail. The catalytic, and hinge domains of MT1-MMP were expressed in Escherichia coli and the active form was generated by successive autoproteolysis of the N- and C-terminal sites during refolding.


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