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MMP-1 Inhibitor Screening Kit (Fluorometric)

Sensitive Assay to Screen MMP-1 Inhibitors, HTS
Catalog #: K794
$495.00

Product Details

Cat # +Size K794-100
Size 100 assays
Detection Method Fluorescence (Ex/Em 490/520 nm)
Applications The kit can be used to screen inhibitors of MMP-1.
Features & Benefits • Simple procedure; takes ~ less than 40 minutes
• Fast and convenient
Kit Components • Assay Buffer
• Substrate
• MMP-1 Enzyme
• Inhibitor Control (1 µM GM 6001)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The Matrix metalloproteinase-1 (MMP-1, Interstitial collagenase, fibroblast collagenase) is a member of a multigene family of calcium-dependent, zinc-containing endoproteinases, the matrix metalloproteinases (MMPs). The MMPs are responsible for the degradation of the extracellular matrix (ECM) including collagens, elastins, gelatin, matrix glycoproteins and proteoglycan during normal development and disease processes. MMPs are regulated by hormones, growth factors and cytokines. MMP-1 belongs to the subclass, the collagenases, and along with MMP-8, and MMP-13 are the only members of the MMP family that are capable of degrading the types I, II and III interstitial collagens with high efficiency. These collagens are primarily found in bone, cartilage and skin. In BioVision’s MMP-1 Inhibitor Screening Kit, MMP-1 hydrolyzes a specific FRET substrate to release a quenched fluorescent group, which can be detected at Ex/Em = 490/520nm. In presence of potent MMP-1 inhibitors the clevage of substrate will be inhibited or stopped. The kit provides a rapid, simple, sensitive, and reliable test suitable as a high throughput screening assay of MMP-1 inhibitors. For comparison of the relative efficacy of test inhibitors, a control inhibitor, GM 6001 (IC₅₀ = 0.4 nM for MMP-1) is included.


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