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MLN-8054

A potent and selective Aurora kinase A inhibitor
Catalog #: B1943

In stock

SKU-Size Size Price Qty
B1943-5 5 mg
$135.00
B1943-25 25 mg
$535.00

Product Details

Alternate Name 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid
Appearance Crystalline solid
CAS # 869363-13-3
Molecular Formula C₂₅H₁₅ClF₂N₄O₂
Molecular Weight 476.86
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml)
SMILES C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O
InChi InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)
InChi Key HHFBDROWDBDFBR-UHFFFAOYSA-N
PubChem CID 11712649
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MLN-8054 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 4 nM). Displays 40-fold selectivity for Aurora A over Aurora B.


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