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ML133 Hydrochloride

An inward-rectifier potassium channel 2 (Kir2) inhibitor
Catalog #: B3097
SKU-Size Size Price Qty
B3097-10 10 mg
$65.00
B3097-50 50 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride
Appearance Off-white solid
CAS # 1222781-70-5
Molecular Formula C₁₉H₂₀ClNO
Molecular Weight 313.82
Purity ≥ 97%
Solubility ~10 mg/ml in DMSO
SMILES COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl
InChi InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H
InChi Key NGQIBUUFXDPHKT-UHFFFAOYSA-N
PubChem CID 44247466
MDL Number MFCD20921521
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20 °C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC₅₀ values of 300 and 76 µM, respectively). ML133 inhibits the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.


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