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Product Details
| Alternate Name | 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride |
|---|---|
| Appearance | Off-white solid |
| CAS # | 1222781-70-5 |
| Molecular Formula | C₁₉H₂₀ClNO |
| Molecular Weight | 313.82 |
| Purity | ≥ 97% |
| Solubility | ~10 mg/ml in DMSO |
| SMILES | COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl |
| InChi | InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H |
| InChi Key | NGQIBUUFXDPHKT-UHFFFAOYSA-N |
| PubChem CID | 44247466 |
| MDL Number | MFCD20921521 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20 °C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC₅₀ values of 300 and 76 µM, respectively). ML133 inhibits the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.
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