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ML130

A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor
Catalog #: 1974
SKU-Size Size Price Qty
1974-5 5 mg
$90.00
1974-25 25 mg
$355.00
More Sizes Get Quote

Product Details

Alternate Name 1-Tosyl-1H-benzo[d]imidazol-2-amine; Nodinitib-1
Appearance White solid
CAS # 799264-47-4
Molecular Formula C₁₄H₁₃N₃O₂S
Molecular Weight 287.34
Purity ≥97% by HPLC
Solubility DMSO
SMILES CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N
InChi InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChi Key SRFABRWQVPCPRG-UHFFFAOYSA-N
PubChem CID 1088438
MDL Number MFCD04322367
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC₅₀ = 0.56±0.04 µM). Displays high selectivity (>36-fold) over MDP-stimulated signaling in reporter cell lines containing both endogenous and overexpressed NOD2 proteins or TNF-⍺-induced NF-kB activation.


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