Product Details
| abID | ab142177 |
|---|---|
| Alternate Name | 1-Tosyl-1H-benzo[d]imidazol-2-amine; Nodinitib-1 |
| Appearance | White solid |
| CAS # | 799264-47-4 |
| Molecular Formula | C₁₄H₁₃N₃O₂S |
| Molecular Weight | 287.34 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N |
| InChi | InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16) |
| InChi Key | SRFABRWQVPCPRG-UHFFFAOYSA-N |
| PubChem CID | 1088438 |
| MDL Number | MFCD04322367 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC₅₀ = 0.56±0.04 µM). Displays high selectivity (>36-fold) over MDP-stimulated signaling in reporter cell lines containing both endogenous and overexpressed NOD2 proteins or TNF-⍺-induced NF-kB activation.
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