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A potent and selective NRF2 inhibitor
Catalog #: B2605
SKU-Size Size Price Qty
B2605-5 5 mg
B2605-25 25 mg
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Product Details

Alternate Name ML385, N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
Peptide Sequence N/A
Appearance White solid
CAS # 846557-71-9
Molecular Formula C₂₉H₂₅N₃O₄S
Molecular Weight 511.59
Purity ≥98% by HPLC
Solubility >25 mg/ml in DMSO
InChi InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33) 14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
PubChem CID 1383822
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ML-385 is a potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 µM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.

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