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ML-228

An activator of the Hypoxia Inducible Factor (HIF) pathway
Catalog #: B2633
SKU-Size Size Price Qty
B2633-1 1 mg
$75.00
B2633-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name CID-46742353 6-phenyl-N-[(4-phenylphenyl)methyl]-3-pyridin-2-yl-1,2,4-triazin-5-amine
Appearance Brown solid
CAS # 1357171-62-0
Molecular Formula C₂₇H₂₁N₅
Molecular Weight 415.49
Purity ≥98% by HPLC
Solubility >40 mg/ml in DMSO
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=C(N=NC(=N3)C4=CC=CC=N4)C5=CC=CC=C5
InChi InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
InChi Key QNRODODTMXCRKU-UHFFFAOYSA-N
PubChem CID 46742353
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
USAGE For Research Use Only! Not For Use in Humans.

Details

ML-228 is an activator of the Hypoxia Inducible Factor (HIF) signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 µM), HIF-1α nuclear translocation assay (EC50 = 1.3 µM), and increased VEGF expression (EC50 = 1.6 µM). Its activity in the HRE assay is blocked by excess iron, suggesting that ML-228 can chelate iron. ML-228 also significantly inhibits ligand binding to several channels, receptors, and transporters, including ERG potassium channel, 5-HT2B and A3 adenosine receptors, and dopamine transporter.


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