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ML-210

A glutathione peroxidase 4 (GPX4) inhibitor
Catalog #: B2710
SKU-Size Size Price Qty
B2710-5 5 mg
$115.00
B2710-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone, DPI10
Peptide Sequence N/A
Appearance Off-white solid
CAS # 1360705-96-9
Molecular Formula C₂₂H₂₀Cl₂N₄O₄
Molecular Weight 475.32
Purity ≥98%
Solubility >20 mg/ml DMSO
SMILES CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]
InChi InChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
InChi Key VIBHJPDPEVVDTB-UHFFFAOYSA-N
PubChem CID 49766530
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the lipoxygenase inhibitor PD 146176 (Cat. No. B2313). ML-210 displays anti-cancer activity.


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