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ML-162

A GPX4 (glutathione peroxidase 4) inhibitor
Catalog #: B2304

In stock

SKU-Size Size Price Qty
B2304-1 1 mg
$85.00
B2304-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
Appearance Crystalline solid
CAS # 1035072-16-2
Molecular Formula C₂₃H₂₂Cl₂N₂O₃S
Molecular Weight 477.4
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
InChi InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)
InChi Key UNVKYJSNMVDZJE-UHFFFAOYSA-N
PubChem CID 3689413
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).


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