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(+)-MK 801 Hydrogen Maleate

A potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist
Catalog #: B2326

In stock

SKU-Size Size Price Qty
B2326-5 5 mg
$75.00
B2326-25 25 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name 10,11-dihydro-5S-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate,Dizocilpine
Appearance White solid
CAS # 77086-22-7
Molecular Formula C₂₀H₁₉NO₄
Molecular Weight 337.37
Purity ≥98% by HPLC
Solubility ~6 mg/ml (H₂O)
>20 mg/ml (DMSO)
SMILES CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O
InChi InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
InChi Key QLTXKCWMEZIHBJ-PJGJYSAQSA-N
PubChem CID 6420042
MDL Number MFCD0082465
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MK-801 is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux. It has been shown to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.


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