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Product Details
| Alternate Name | 10,11-dihydro-5S-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate,Dizocilpine |
|---|---|
| Appearance | White solid |
| CAS # | 77086-22-7 |
| Molecular Formula | C₂₀H₁₉NO₄ |
| Molecular Weight | 337.37 |
| Purity | ≥98% by HPLC |
| Solubility | ~6 mg/ml (H₂O) >20 mg/ml (DMSO) |
| SMILES | CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O |
| InChi | InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1 |
| InChi Key | QLTXKCWMEZIHBJ-PJGJYSAQSA-N |
| PubChem CID | 6420042 |
| MDL Number | MFCD0082465 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
MK-801 is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux. It has been shown to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.
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