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MK-591, Free acid

A potent 5-Lipoxygenase-activating protein (FLAP) inhibitor
Catalog #: B2520
SKU-Size Size Price Qty
B2520-1 1 mg
B2520-5 5 mg
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Product Details

Alternate Name 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid; L686,708; L686,708; L-686,708; MK591; Quiflapon; MK 591
Appearance Crystalline solid
CAS # 136668-42-3
Molecular Formula C₃₄H₃₅ClN₂O₃S
Molecular Weight 587.17
Purity ≥98%
Solubility >40 mg/ml in DMSO
InChi InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22) 30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)
PubChem CID 60923
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


MK-0591 is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs; potently inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC₅₀ of 3.1 and 6.1 nM, respectively.

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