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A potent and selective PARP-1 and PARP-2 inhibitor
Catalog #: 9462
SKU-Size Size Price Qty
9462-5 5 mg
9462-25 25 mg
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Product Details

Alternate Name 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide; Niraparib
Appearance Light yellow solid
CAS # 1038915-60-4
Molecular Formula C₁₉H₂₀N₄O
Molecular Weight 320.39
Purity ≥98% by HPLC
Solubility DMSO (>4 mg/ml)
InChi InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
PubChem CID 24958200
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.

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