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MK-4101

Aselective Hedgehog (Hh) signaling pathway inhibitor.
Catalog #: B1255
SKU-Size Size Price Qty
B1255-5 5 mg
$155.00
B1255-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name  5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole
Appearance Crystaline solid
CAS # 935273-79-3 
Molecular Formula C₂₄H₂₄F₅N₅O 
Molecular Weight 493.48
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CN1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(C5)(F)F)C6=CC=CC=C6C(F)(F)F
InChi InChI=1S/C24H24F5N5O/c1-34-17(15-4-2-3-5-16(15)24(27,28)29)31-32-20(34)22-9-6-21(7-10-22,8-11-22)19-30-18(35-33-19)14-12-23(25,26)13-14/h2-5,14H,6-13H2,1H3
InChi Key HKJOIWLYDJCTQR-UHFFFAOYSA-N
PubChem CID 449097
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MK-4101 is a potent and selective inhibitor of the Hedgehog (Hh) signaling pathway. It displays potent activity against medulloblastoma and Basal Cell Carcinoma (BCC). MK-4101 shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. 


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