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MK-8745

An Aurora-A specific inhibitor
Catalog #: B1942

In stock

SKU-Size Size Price Qty
B1942-5 5 mg
$95.00
B1942-25 25 mg
$375.00

Product Details

Alternate Name (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone
Appearance Crystalline solid
CAS # 885325-71-3
Molecular Formula C₂₀H₁₉ClFN₅OS
Molecular Weight 431.91
Purity ≥98% by HPLC
Solubility DMSO (>18 mg/ml)
SMILES C1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F
InChi InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
InChi Key YCRFPWKUUNKNDN-UHFFFAOYSA-N
PubChem CID 11676373
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.


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