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A potent and reversible γ-secretase inhibitor
Catalog #: B1980

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SKU-Size Size Price Qty
B1980-1 1 mg
B1980-5 5 mg
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Product Details

Alternate Name 3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
Appearance Crystalline solid
CAS # 471905-41-6
Molecular Formula C₂₁H₂₁ClF₂O₄S
Molecular Weight 442.9
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
InChi InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
PubChem CID 9803433
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


MK-0752 is a potent and reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells (IC₅₀ = 5 nM). Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel (Cat. No. 2232) in mice with breast cancer tumors.

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