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Mitoxantrone

A topoisomerase II inhibitor
Catalog #: 1885
SKU-Size Size Price Qty
1885-50 50 mg
$80.00
1885-250 250 mg
$285.00
More Sizes Get Quote

Product Details

Alternate Name 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione
Appearance Dark blue soild
CAS # 65271-80-9
Molecular Formula C₂₂H₂₈N₄O₆
Molecular Weight 444.48
Purity ≥98%
Solubility DMSO (~88 mg/ml)
SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
InChi InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
InChi Key KKZJGLLVHKMTCM-UHFFFAOYSA-N
PubChem CID 4212
MDL Number MFCD00242942
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.


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