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Miransertib

An allosteric, pan-Akt inhibitor
Catalog #: B1931
SKU-Size Size Price Qty
B1931-5 5 mg
$145.00
B1931-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine; ARQ-092
Appearance Crystalline solid
CAS # 1313881-70-7
Molecular Formula C₂₇H₂₄N₆
Molecular Weight 432.53
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
InChi InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
InChi Key HNFMVVHMKGFCMB-UHFFFAOYSA-N
PubChem CID 53262401
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Miransertib is an allosteric, pan-Akt inhibitor (IC₅₀s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). It is selective for Akt isoforms over a panel of 303 other kinases. It binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway.


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