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MIF-Antagonist, ISO-1

A migration inhibitory factor (MIF) antagonist
Catalog #: 1895
$100.00

Product Details

Cat # +Size 1895-5
Size 5 mg
Alternate Name (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Appearance Off-white solid
CAS # 478336-92-4
Molecular Formula C₁₂H₁₃NO₄
Molecular Weight 235.24
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml)
SMILES COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1
InChi InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3
InChi Key CLVQGFPQFNASJH-UHFFFAOYSA-N
PubChem CID 6098948
MDL Number MFCD22376813
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.


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