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Microcystin-LR

A protein phosphatase 1 (PP1) inhibitor
Catalog #: 1840
SKU-Size Size Price Qty
1840-100 100 µg
$100.00
1840-500 500 µg
$355.00
More Sizes Get Quote

Product Details

Alternate Name Cyanoginosin-LR
Appearance Whitish film
CAS # 101043-37-2
Molecular Formula C₄₉H₇₄N₁₀O₁₂
Molecular Weight 995.17
Purity ≥95% by HPLC
Solubility DMSO or EtOH or MeOH
SMILES CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C
InChi InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
InChi Key ZYZCGGRZINLQBL-GWRQVWKTSA-N
PubChem CID 445434
MDL Number MFCD01774058
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A hepatotoxic cyclic heptapeptide toxin produced by cyanobacteria. A selective inhibitor of protein phosphatase 1 (PP1) (IC₅₀ = 1.7 nM) and protein phosphatase 2A (PP2A) (IC₅₀ = 0.04 nM). Less sensitive to PP2B and does not inhibit PP2C up to 4 µM.


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