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MI-nc (hydrochloride)

A weak inhibitor of the menin-MLL interaction
Catalog #: B2816
SKU-Size Size Price Qty
B2816-1 1 mg
B2816-5 5 mg
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Product Details

Alternate Name MI-nc, 6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine,dihydrochloride
Appearance Crystalline solid
CAS # 1934302-23-4
Molecular Formula C₁₄H₁₈Cl₂N₆S₂
Molecular Weight 405.36
Purity ≥98%
Solubility 0.1 mg/ml in Ethanol
1.3 mg/ml in DMSO
0.16 mg/ml in PBS, pH 7.2
InChi 1S/C14H16N6S2.2ClH/c1-2-10-7-11-12(15-8-16-13(11)22-10)19-3-5-20(6-4-19)14-18-17-9-21-14;;/h7-9H,2-6H2,1H3;2*1H
PubChem CID 132989422
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


MI-nc (hydrochloride) is a weak inhibitor of the menin-MLL interaction. Menin is a tumor suppressor protein. Menin is a part of the MLL (Mixed Lineage Leukemia) SET1-like histone methyl transferase complex. Association of menin with MLL fusion proteins causes oncogenic transformation. MI-nc (hydrochloride) showed very weak inhibition of the menin-MLL interaction (IC₅₀ = 193 μM) in vitro. It serves as a negative control for MI-2 which is a potent menin-MLL interaction inhibitor (IC₅₀ = 0.45 μM).

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