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MI-3

A Menin-MLL (Mixed linage leukemia) protein interaction inhibitor
Catalog #: B1834
SKU-Size Size Price Qty
B1834-5 5 mg
$135.00
B1834-25 25 mg
$540.00
More Sizes Get Quote

Product Details

Alternate Name 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine; Menin-MLL inhibitor 3
Appearance Crystalline solid
CAS # 1271738-59-0
Molecular Formula C₁₈H₂₅N₅S₂
Molecular Weight 375.55
Purity ≥98% by HPLC
Solubility DMSO (~5 mg/ml)
SMILES CC(C)C1=NC(=C2C=CSC2=N1)N3CCN(CC3)C4=NCC(S4)(C)C
InChi InChI=1S/C18H25N5S2/c1-12(2)14-20-15(13-5-10-24-16(13)21-14)22-6-8-23(9-7-22)17-19-11-18(3,4)25-17/h5,10,12H,6-9,11H2,1-4H3
InChi Key BYEYBIAXHABAEB-UHFFFAOYSA-N
PubChem CID 71651135
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MI-3 is a Menin-MLL (Mixed linage leukemia) protein interaction inhibitor with an IC₅₀ of 648 ± 25 nM. MLL protein is a histone methyltransferase that positively regulates gene transcription. However, MLL gene is a common target for chromosomal translocations found in some leukemia. 


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