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MI-463

A potent inhibitor of Menin-MLL interaction
Catalog #: B2668
SKU-Size Size Price Qty
B2668-5 5 mg
$135.00
B2668-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile; MI463
Appearance Crystalline solid
CAS # 1628317-18-9
Molecular Formula C₂₄H₂₃F₃N₆S
Molecular Weight 484.55
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F
InChi InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25,26)27)34-23(20)30-13-29-22/h2-3,8-9,13,16,31H,4-7,10,12H2,1H3,(H,29,30,32)
InChi Key DZACSLYTXLZAAF-UHFFFAOYSA-N
PubChem CID 90455046
MDL Number MFCD28506301
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MI-463 is a potent inhibitor of Menin-MLL interaction (IC₅₀ = 15.3 nM). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through on-target activity without causing toxicity. MI-463 induces strong inhibition of tumor growth with once daily intraperitoneal administration.


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