A proteasome inhibitor
Catalog #: 1703 | abID:

Product Details

Alternate Name Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Peptide Sequence Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Appearance White to off-white solid
CAS # 133407-82-6
Molecular Formula C₂₆H₄₁N₃O₅
Molecular Weight 475.6
Purity ≥98% by HPLC
Solubility DMSO (10 mg/ml)
InChi InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
PubChem CID 462382
MDL Number MFCD00674886
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC₅₀ = 3 µM). Prevents γ-secretase cleavage. Calpain inhibitors such as MDL28170 and MG132 may interfere with proteolytic processing of coronavirus S protein thereby preventing virus entry.

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