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Product Details
| Alternate Name | Z-Leu-Leu-Leu-CHO; Z-LLL-CHO |
|---|---|
| Peptide Sequence | Z-Leu-Leu-Leu-CHO; Z-LLL-CHO |
| Appearance | White to off-white solid |
| CAS # | 133407-82-6 |
| Molecular Formula | C₂₆H₄₁N₃O₅ |
| Molecular Weight | 475.6 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (10 mg/ml) |
| SMILES | CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1 |
| InChi Key | TZYWCYJVHRLUCT-VABKMULXSA-N |
| PubChem CID | 462382 |
| MDL Number | MFCD00674886 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC₅₀ = 3 µM). Prevents γ-secretase cleavage. Calpain inhibitors such as MDL28170 and MG132 may interfere with proteolytic processing of coronavirus S protein thereby preventing virus entry.
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