A proteasome inhibitor
Catalog #: 1831 | abID:

Product Details

Alternate Name Z-LL-NVa-CHO; Z-Leu-Leu-Nva-CHO
Appearance White to off-white solid
Molecular Formula C₂₅H₃₉N₃O₅
Molecular Weight 461.59
Purity ≥95% by HPLC
Solubility DMSO
InChi InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
PubChem CID 9868928
MDL Number MFCD00671410
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, reversible proteasome inhibitor with Ki of 21 nM for 20S proteasome and 35 nM for 26S proteasome. The inhibition of proteasome was through specific inhibition of chymotrypsin-like activity of the proteasome. Also shown to induce apoptosis in Rat-1 and PC12 cells via a p3-independent pathway.

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