Metformin, Hydrochloride

An AMPK activator

Metformin, Hydrochloride is available from Abcam as ab120847.
Catalog #: 1691 | abID: ab120847

Product Details

abID ab120847
Cat # +Size 1691-5G
Size 5 g
Alternate Name 1,1-Dimethylbioguanide Hydrochloride
Appearance White to off-white solid
CAS # 1115-70-4
Molecular Formula C₄H₁₁N₅. HCl
Molecular Weight 165.62
Purity ≥98%
Solubility H₂O (50 mg/ml)
InChi InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
PubChem CID 14219
MDL Number MFCD00012582
Handling Protect from air and moisture
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


An anti-diabetic agent. It reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Metformin helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain, and is the only anti-diabetic drug that has been conclusively shown to prevent the cardiovascular complications of diabetes.

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Wu Duan, Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production Am J Transl Res, Apr. 19; 31105845.
Rajni Kumari, Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis. Nat Commun., Sep. 2019; 31534141.
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