Product Details
| abID | ab120847 |
|---|---|
| Cat # +Size | 1691-5G |
| Size | 5 g |
| Alternate Name | 1,1-Dimethylbioguanide Hydrochloride |
| Appearance | White to off-white solid |
| CAS # | 1115-70-4 |
| Molecular Formula | C₄H₁₁N₅. HCl |
| Molecular Weight | 165.62 |
| Purity | ≥98% |
| Solubility | H₂O (50 mg/ml) |
| SMILES | CN(C)C(=N)N=C(N)N.Cl |
| InChi | InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H |
| InChi Key | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| PubChem CID | 14219 |
| MDL Number | MFCD00012582 |
| Handling | Protect from air and moisture |
| Storage Conditions | 4°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
An anti-diabetic agent. It reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Metformin helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain, and is the only anti-diabetic drug that has been conclusively shown to prevent the cardiovascular complications of diabetes.
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Wu Duan, Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production Am J Transl Res, Apr. 19; 31105845.
Rajni Kumari, Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis. Nat Commun., Sep. 2019; 31534141.
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