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MET, Active

A proto-oncogene 
Catalog #: 7771
$295.00

Product Details

Cat # +Size 7771-5
Size 5 μg
Alternate Name MET, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Short name=SF receptor, Tyrosine-protein kinase Met
Gene Symbol MET
Accession # X96786
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Molecular Weight 74.0 kDa
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kd (α) and 145 kd (β). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue (1). Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion (2).


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