Product Details
| Cat # +Size | 3518-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | Mek 1/2 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide from human Mek1/2 |
| Accession # | NP_002746.1 |
| Gene ID | 5579478 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot |
| Application & Usage | Western blotting (1:500-1000). However, the optimal concentrations should be determined individually. The antibody recognizes 45 kDa Mek1/2 of human, mouse, and rat origins. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
MAP kinase kinase 1 (Mek1), also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Mek1 and Mek2 are involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek1 and Mek2 are activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway.
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