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MEK-162

A potent and selective MEK1/2 inhibitor
Catalog #: 2254
SKU-Size Size Price Qty
2254-5 5 mg
$65.00
2254-25 25 mg
$245.00
More Sizes Get Quote

Product Details

Alternate Name 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; methyl-1H-benzimidazole-6-carboxamide; ARRY
Appearance White to off-white solid
CAS # 606143-89-9
Molecular Formula C₁₇H₁₅BrF₂N₄O₃
Molecular Weight 441.23
Purity ≥98% by HPLC
Solubility DMSO (~100 mM)
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
InChi InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChi Key ACWZRVQXLIRSDF-UHFFFAOYSA-N
PubChem CID 10288191
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent, non-ATP competitive inhibitor of MEK1/2 (IC₅₀ = 12 nM) and cellular pERK (IC₅₀ = 11 nM). Selective against a panel of other 220 kinases (displays no activity even at 10 µM).


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