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Product Details
| Alternate Name | 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide |
|---|---|
| Appearance | White solid |
| CAS # | 1445251-22-8 |
| Molecular Formula | C₁₉H₁₉N₃O₂ |
| Molecular Weight | 321.37 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (~30 mg/ml) or EtOH (~4 mg/ml) |
| SMILES | CC(C1=CC=CC=C1)NC(=O)CCC2=NC(=O)C3=CC=CC=C3N2 |
| InChi | InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1 |
| InChi Key | QIHBWVVVRYYYRO-ZDUSSCGKSA-N |
| PubChem CID | 71571526 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30 µM, respectively).
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