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MCP-1 (MCAF), human recombinant

based on 1 citations in multiple journalsMCP-1 (MCAF), human recombinant14.1 4
Chemoattractant for monocytes and basophils
Catalog #: 4222
SKU-Size Size Price Qty
4222-20 20 μg
$180.00
4222-100 100 μg
$495.00
4222-1000 1 mg
$2,750.00
More Sizes Get Quote

Product Details

Alternate Name HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2
Gene Symbol MCP-1
Gene ID 20296
Accession # P10148
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 8.6 kDa
Purity by SDS-PAGE ≥98%
Endotoxin Level <0.01 ng/μg
Biological Activity The activity is determined by its ability to chemoattract human monocytes at 4 - 15 ng/ml.
Reconstitution Instructions Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a conce
Amino Acid Sequence QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Monocyte Chemoattractant Protein 1 (MCP-1), also known as CCL2, is thought to be produced by injured or infected tissues. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit memory T cells, monocytes and dendritic cells. Recombinant mouse MCP-1 is a non-glycosylated protein, containing 76 amino acids and having a molecular mass of 8.6 kDa.


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Stephen P. Gray et al., NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis. Circulation, May 2013; 127: 1888 - 1902.
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