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MCC950 sodium

A potent and selective NLRP3 inflammasome inhibitor
Catalog #: 9686
SKU-Size Size Price Qty
9686-1 1 mg
$115.00
9686-5 5 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CP-456,773; CRID3
Appearance Off-white solid
CAS # 256373-96-3
Molecular Formula C₂₀H₂₃N₂NaO₅S
Molecular Weight 426.46
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml) or H2O (>30 mg/ml)
SMILES CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
InChi InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChi Key LFQQNXFKPNZRFT-UHFFFAOYSA-M
PubChem CID 91826093
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.


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