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MCC950 (Free base)

potent and selective NLRP3 inflammasome inhibitor.
Catalog #: B1031
SKU-Size Size Price Qty
B1031-1 1 mg
$95.00
B1031-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide; CP-456,773; CRID3
Appearance Light yellow to yellow solid
CAS # 210826-40-7
Molecular Formula C₂₀H₂₄N₂O₅S
Molecular Weight 404.48
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml)
SMILES CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O
InChi InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23)
InChi Key HUUSXLKCTQDPGL-UHFFFAOYSA-N
PubChem CID 9910393
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MCC950 is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.


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