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Product Details
| Alternate Name | Caspase-1 substrate, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH., ACE2 substrate |
|---|---|
| Peptide Sequence | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH |
| Appearance | White to yellow solid |
| CAS # | N/A |
| Molecular Formula | C₅₃H₆₄N₁₀O₁₉ |
| Molecular Weight | 1145.1 |
| Purity | ≥95% by HPLC |
| Solubility | >5 mg/ml DMSO |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
MCA-YVADAP-K(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2). Upon cleavage by caspase-1 or ACE2, 7-methoxycoumarin-4-acetyl (MCA) is released and its fluorescence can be used to estimate enzyme activity. MCA displays excitation/emission maxima of 328/420 nm, respectively.
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