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Massonianoside B

A selective DOT1L inhibitor
Catalog #: B2537
SKU-Size Size Price Qty
B2537-500 500 µg
B2537-1000 1 mg
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Product Details

Alternate Name MA, (2S,3R,4R,5R,6S)-2-[4-[(2S,3R)-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2,3-dihydro-1-benzofuran-2-yl]-2-methoxyphenoxy]-6-methyloxane-3,4,5-triol
Peptide Sequence N/A
Appearance Lyophilized solid
CAS # 188300-19-8
Molecular Formula C₂₅H₃₂O₁₀
Molecular Weight 492.52
Purity ≥95%
Solubility in DMSO
InChi InChI=1S/C25H32O10/c1-12-20(29)21(30)22(31)25(33-12)34-18-6-5-14(10-19(18)32-2)23-16(11-27)15-8-13(4-3-7-26)9-17(28)24(15)35-23/h5-6,8-10,12,16,20-23,25-31H,3-4,7,11H2,1-2H3/t12-,16-,20-,21+,22+,23+,25-/m0/s1
PubChem CID 76311962
MDL Number MFCD20274727
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Massonianoside B (MA) is a structurally unique natural product inhibitor of DOT1L with an IC50 value of 399 nM. It displays high selectivity for DOT1L over other S-adenosylmethionine (SAM)-dependent PMTs (Protein methyltransferases).

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