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MART-1/Melan-A, mouse recombinant

Pure mouse recombinant full length MART-1/Melan-A.
Catalog #: 4824
SKU-Size Size Price Qty
4824-5 5 μg
$225.00
4824-50 50 μg
$795.00
4824-1000 1 mg
$5,900.00
More Sizes Get Quote

Product Details

Alternate Name Melanoma antigen recognized by T-cells 1, Antigen LB39-AA, Antigen SK29-AA, MART-1, Melan-A
Gene Symbol Melan-A
Gene ID 77836
Accession # Q2TA50
Source E. coli
Appearance Liquid
Physical Form Description MART-1/Melan-A protein is in 50 mM Tris, pH 7.5, 100 mM NaCl, 20 mM β-mercaptoethanol, and 20%Glycerol.
Molecular Weight 17.6 kDa
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

MART-1 (also known as Melan-A) is a melanocyte differentiation antigen or marker recognized by autologous cytotoxic T lymphocytes. It is a membrane protein with one transmembrane peptide. Melan-A is expressed by a large proportion of melanoma tumors, both melanotic and amelanotic and by melanoma cell lines. It is present in melanocytes of normal skin and retina, nevi and in more than 85% of melanomas. Melan-A/MART-1 is not expressed by non-melanoma malignancies. It is recognized by autologous cytotoxic T lymphocytes. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Mouse MART-1 is purified by proprietary chromatographic techniques.


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