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Marimastat

A broad spectrum MMP inhibitor
Catalog #: 1790
SKU-Size Size Price Qty
1790-1 1 mg
$110.00
1790-5 5 mg
$415.00
More Sizes Get Quote

Product Details

Alternate Name (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide; BB-2516; TA-2516; Marimistat
Appearance White solid
CAS # 154039-60-8
Molecular Formula C₁₅H₂₉N₃O₅
Molecular Weight 331.41
Purity ≥98% by HPLC
Solubility DMSO (100 mM)
SMILES CC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C
InChi InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
InChi Key OCSMOTCMPXTDND-OUAUKWLOSA-N
PubChem CID 119031
MDL Number MFCD00866242
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A broad spectrum matrix metalloprotease (MMP) inhibitor with IC₅₀ values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.


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