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Mapracorat

a selective glucocorticoid receptor agonist
Catalog #: B3078
SKU-Size Size Price Qty
B3078-1 1 mg
$95.00
B3078-5 5 mg
$380.00
More Sizes Get Quote

Product Details

Alternate Name BOL-303242X; ZK-245186; (2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol; 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-gamma,gamma-dimethyl-alpha-(((2-methyl-5-quinolinyl)amino)methyl)-alpha-(trifluoromethyl)-, (alphaR)-
Appearance Yellow crystals
CAS # 887375-26-0
Molecular Formula C₂₅H₂₆F₄N₂O₂
Molecular Weight 462.49
Purity >98%
Solubility ~33 mg/ml in DMSO
SMILES CC1=NC2=C(C=C1)C(=CC=C2)NCC(CC(C)(C)C3=CC(=CC4=C3OCC4)F)(C(F)(F)F)O
InChi InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1
InChi Key VJGFOYBQOIPQFY-XMMPIXPASA-N
PubChem CID 24795088
MDL Number MFCD19443722
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis and Eczema. It inhibits TNFα secretion from activated canine peripheral blood derived mononuclear cells with an IC₅₀ value of approximately 0.2 nM. It shows beneficial effects in inflammatory and pruritic skin diseases in dogs.


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