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Manumycin A

A potent rasfarnesyltransferase (FTase) inhibitor
Catalog #: 2333
SKU-Size Size Price Qty
2333-1 1 mg
2333-5 5 mg
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Product Details

Alternate Name NSC-622141; UFC 1C
Appearance Yellow to brown solid
CAS # 52665-74-4
Molecular Formula C₃₁H₃₈N₂O
Molecular Weight 550.64
Purity ≥96% by HPLC
Solubility DMSO
InChi InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
PubChem CID 6438330
MDL Number MFCD00920782
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC₅₀ = 180 µM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.

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