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MALT1 Inhibitor, MI-2

A potent MALT1 inhibitor
Catalog #: B2368

In stock

SKU-Size Size Price Qty
B2368-5 5 mg
$155.00
B2368-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name MI-2,2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide
Appearance Off-white solid
CAS # 1047953-91-2
Molecular Formula C₁₉H₁₇Cl₃N₄O₃
Molecular Weight 455.72
Purity ≥98% by HPLC
Solubility >5 mg/ml (EtOH),>40 mg/ml (DMSO)
SMILES COCCOC1=NN(C(=N1)C2=CC(=C(C=C2)Cl)Cl)C3=CC=C(C=C3)NC(=O)CCl
InChi InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
InChi Key TWJGQZBSEMDPQP-UHFFFAOYSA-N
PubChem CID 45942672
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MALT1 inhibitor MI-2 is a potent inhibitor of the paracaspase MALT1 (Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) (IC₅₀ = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.


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