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MAK-683

aApotent EED (embryonic ectoderm development protein) inhibitor
Catalog #: B1972
SKU-Size Size Price Qty
B1972-5 5 mg
$135.00
B1972-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
Appearance Crystalline solid
CAS # 1951408-58-4
Molecular Formula C₂₀H₁₇FN₆O
Molecular Weight 376.39
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml)
SMILES CC1=C(C=CC=N1)C2=CN=C(N3C2=NN=C3)NCC4=C(C=CC5=C4CCO5)F
InChi InChI=1S/C20H17FN6O/c1-12-13(3-2-7-22-12)16-10-24-20(27-11-25-26-19(16)27)23-9-15-14-6-8-28-18(14)5-4-17(15)21/h2-5,7,10-11H,6,8-9H2,1H3,(H,23,24)
InChi Key XLIBABIFOBYHSV-UHFFFAOYSA-N
PubChem CID 121412508
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MAK-683 is a potent EED (embryonic ectoderm development protein) inhibitor and an allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3-binding pocket and prevents the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2).


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